Immunosuppression in Hamsters with Progressive Visceral Leishmaniasis Is Associated with an Impairment of Protein Kinase C Activity in Their Lymphocytes That Can Be Partially Reversed by Okadaic Acid or Anti-Transforming Growth Factor Antibody
نویسندگان
چکیده
Immunosuppression in Hamsters with Progressive Visceral Leishmaniasis Is Associated with an Impairment of Protein Kinase C Activity in Their Lymphocytes That Can Be Partially Reversed by Okadaic Acid or Anti-Transforming Growth Factor Antibody Ananda Mookerjee, Parimal C. Sen, and Asoke C. Ghose* Departments of Microbiology and Chemistry, Bose Institute, P-1/12 CIT Scheme VII M, Kolkata 700 054, India
منابع مشابه
Transforming growth factor beta and immunosuppression in experimental visceral leishmaniasis.
Hamsters infected with Leishmania donovani develop a disease similar to human kala-azar. They present hypergammaglobulinemia, and their T cells do not respond to parasite antigens. This unresponsiveness has been primarily ascribed to defects in antigen-presenting cells (APCs), because these cells are unable to stimulate proliferation of parasite-specific T cells from immunized animals. In this ...
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